Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis-Reference-Cited by-同舟云学术

Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis

Published:2020-06-03 Issue:546 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Santovito Donato¹²^ORCID,Egea Virginia¹^ORCID,Bidzhekov Kiril¹,Natarelli Lucia¹²,Mourão André³^ORCID,Blanchet Xavier¹^ORCID,Wichapong Kanin⁴^ORCID,Aslani Maria¹²^ORCID,Brunßen Coy⁵^ORCID,Horckmans Michael¹⁶,Hristov Michael¹,Geerlof Arie³,Lutgens Esther¹²⁷^ORCID,Daemen Mat J.A.P.⁷^ORCID,Hackeng Tilman⁴^ORCID,Ries Christian¹^ORCID,Chavakis Triantafyllos⁸,Morawietz Henning⁵^ORCID,Naumann Ronald⁹,von Hundelshausen Philipp¹²^ORCID,Steffens Sabine¹²^ORCID,Duchêne Johan¹^ORCID,Megens Remco T.A.¹⁴^ORCID,Sattler Michael³¹⁰^ORCID,Weber Christian¹²⁴¹¹^ORCID

Affiliation:

1. Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.

2. German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, D-80336 Munich, Germany.

3. Institute of Structural Biolology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany.

4. Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229HX Maastricht, Netherlands.

5. Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Faculty of Medicine, TU Dresden, D-01307 Dresden, Germany.

6. Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles (ULB), B-1070 Brussels, Belgium.

7. Department of Medical Biochemistry and Pathology, Amsterdam University Medical Centers, Amsterdam School of Cardiovascular Sciences (ACS), 1081HZ Amsterdam, Netherlands.

8. Institute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, TU Dresden, D-01307 Dresden, Germany.

9. Max-Planck-Institute of Molecular Cell Biology and Genetics, D-01307 Dresden, Germany.

10. Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department of Chemistry, Technical University of Munich, D-85747 Garching, Germany.

11. Munich Cluster for Systems Neurology (SyNergy), D-81377 Munich, Germany.

Abstract

Autophagy-driven nuclear transfer of miR-126-5p guided by Mex3a enables direct inhibition of caspase-3 and protects against atherosclerosis.

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference78 articles.

1. Metazoan MicroRNAs