A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

Author:

Davis Emily J.12ORCID,Broestl Lauren1ORCID,Abdulai-Saiku Samira1ORCID,Worden Kurtresha1ORCID,Bonham Luke W.13ORCID,Miñones-Moyano Elena1ORCID,Moreno Arturo J.1ORCID,Wang Dan1,Chang Kevin1ORCID,Williams Gina14,Garay Bayardo I.1ORCID,Lobach Iryna5,Devidze Nino6,Kim Daniel6,Anderson-Bergman Cliff7ORCID,Yu Gui-Qiu6,White Charles C.89ORCID,Harris Julie A.10ORCID,Miller Bruce L.13ORCID,Bennett David A.11ORCID,Arnold Arthur P.12ORCID,De Jager Phil L.9ORCID,Palop Jorge J.1246ORCID,Panning Barbara13,Yokoyama Jennifer S.1314,Mucke Lennart1246ORCID,Dubal Dena B.124ORCID

Affiliation:

1. Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

3. Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94158, USA.

4. Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.

5. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.

6. Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.

7. Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

8. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

9. Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.

10. Allen Institute for Brain Science, Seattle, WA 98109, USA.

11. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.

12. Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

13. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

14. Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

The second X chromosome confers resilience in a mouse model of Alzheimer’s disease potentially through the X-linked gene Kdm6a .

Funder

National Science Foundation

National Institutes of Health

Larry L. Hillblom Foundation

American Federation for Aging Research

Glenn Foundation for Medical Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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