A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1-Reference-Cited by-同舟云学术

A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1

Published:2020-05-20 Issue:544 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Roestenberg Meta¹²^ORCID,Walk Jona³⁴^ORCID,van der Boor Saskia C.³,Langenberg Marijke C. C.¹,Hoogerwerf Marie-Astrid¹^ORCID,Janse Jacqueline J.¹,Manurung Mikhael¹,Yap X. Zen³,García Amanda Fabra³^ORCID,Koopman Jan Pieter R.¹,Meij Pauline⁵,Wessels Els⁶,Teelen Karina³,van Waardenburg Youri M.³,van de Vegte-Bolmer Marga³,van Gemert Geert Jan³,Visser Leo G.²^ORCID,van der Ven André J. A. M.⁴^ORCID,de Mast Quirijn⁴,Natasha K. C.⁷,Abebe Yonas⁷,Murshedkar Tooba⁷,Billingsley Peter F.⁷^ORCID,Richie Tom L.⁷^ORCID,Sim B. Kim Lee⁷^ORCID,Janse Chris J.¹,Hoffman Stephen L.⁷^ORCID,Khan Shahid M.¹^ORCID,Sauerwein Robert W.³^ORCID

Affiliation:

1. Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

2. Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

3. Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

4. Radboudumc Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

5. Interdivisional GMP Facility, Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

6. Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

7. Sanaria Inc., Rockville, MD 20850, USA.

Abstract

The genetically attenuated malaria vaccine PfSPZ-GA1 is safe, immunogenic, and has suboptimal protective efficacy in people.

Funder

Leiden University Medical Center

Radboud University Medical Center

Sanaria

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference33 articles.

1. World Health Organization WHO Malaria Report 2019 (World Health Organization 2019).

2. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

3. Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

4. Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial

5. Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults

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