SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Author:

Montgomery Magdalene K.1ORCID,Bayliss Jacqueline1ORCID,Devereux Camille1ORCID,Bezawork-Geleta Ayenachew1,Roberts David2ORCID,Huang Cheng3ORCID,Schittenhelm Ralf B.3ORCID,Ryan Andrew4ORCID,Townley Scott L.5ORCID,Selth Luke A.56ORCID,Biden Trevor J.7,Steinberg Gregory R.8ORCID,Samocha-Bonet Dorit79ORCID,Meex Ruth C. R.210ORCID,Watt Matthew J.1ORCID

Affiliation:

1. Department of Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.

2. Department of Physiology, Monash University, Melbourne, VIC 3800, Australia.

3. Proteomics and Metabolomics Facility, Monash University, Melbourne, VIC 3800, Australia.

4. TissuPath, Mount Waverley, VIC 3149, Australia.

5. Dame Roma Mitchell Cancer Research Laboratories and Freemasons Foundation Centre for Men’s Health, Adelaide Medical School, University of Adelaide, SA 5005, Australia.

6. Flinders Centre for Innovation in Cancer and Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.

7. Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

8. Division of Endocrinology and Metabolism, Department of Medicine, the Department of Biochemistry and Biomedical Sciences and the Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.

9. St. Vincent’s Clinical School, Faculty of Medicine, University of NSW, Sydney, NSW 2052, Australia.

10. Department of Human Biology, Maastricht University Medical Centre, Maastricht 6229, Netherlands.

Abstract

SMOC1 is a liver-secreted glucose-responsive protein that improves glycemic control through CREB-mediated suppression of hepatic glucose output.

Funder

European Commission

National Health and Medical Research Council

Canada Research Chairs

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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