Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep

Author:

Contessotto Paolo1ORCID,Orbanić Doriana2ORCID,Da Costa Mark1ORCID,Jin Chunsheng3ORCID,Owens Peter4ORCID,Chantepie Sandrine5ORCID,Chinello Clizia6ORCID,Newell John7ORCID,Magni Fulvio6ORCID,Papy-Garcia Dulce5ORCID,Karlsson Niclas G.3,Kilcoyne Michelle8ORCID,Dockery Peter4ORCID,Rodríguez-Cabello José C.2ORCID,Pandit Abhay1ORCID

Affiliation:

1. CÚRAM SFI Research Centre for Medical Devices, National University of Ireland Galway, Galway, Ireland.

2. Group for Advanced Materials and Nanobiotechnology (BIOFORGE Lab), CIBER-BBN, University of Valladolid, Valladolid, Spain.

3. Department of Medical Biochemistry, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

4. Centre for Microscopy and Imaging, Anatomy, School of Medicine, National University of Ireland Galway, Galway, Ireland.

5. Laboratory Cell Growth, Tissue Repair, and Regeneration (CRRET), EA UPEC 4397/ERL CNRS 9215, University Paris Est, Créteil, France.

6. Clinical Proteomics and Metabolomics Unit, School of Medicine and Surgery, University of Milano-Bicocca, Vedano al Lambro, Italy.

7. School of Mathematics, Statistics, and Applied Mathematics, National University of Ireland Galway, Galway, Ireland.

8. Carbohydrate Signalling Group, Microbiology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.

Abstract

An injectable functionalized elastin-inspired hydrogel improves cardiac functional response in sheep and preserves cardiomyocytes in the border zone.

Funder

Science Foundation Ireland

EU

EU FP7

Ministry of Science of the Spanish Government

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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