Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

Author:

Frankowski Kevin J.1ORCID,Wang Chen2,Patnaik Samarjit3ORCID,Schoenen Frank J.1,Southall Noel3ORCID,Li Dandan4,Teper Yaroslav4,Sun Wei3ORCID,Kandela Irawati5ORCID,Hu Deqing6,Dextras Christopher3ORCID,Knotts Zachary4ORCID,Bian Yansong4,Norton John2,Titus Steve3,Lewandowska Marzena A.2,Wen Yiping2,Farley Katherine I.7ORCID,Griner Lesley Mathews3ORCID,Sultan Jamey3ORCID,Meng Zhaojing8ORCID,Zhou Ming8ORCID,Vilimas Tomas9,Powers Astin S.10ORCID,Kozlov Serguei9ORCID,Nagashima Kunio11ORCID,Quadri Humair S.4ORCID,Fang Min12,Long Charles2ORCID,Khanolkar Ojus2,Chen Warren2,Kang Jinsol2,Huang Helen2,Chow Eric2ORCID,Goldberg Esthermanya2ORCID,Feldman Coral2,Xi Romi2,Kim Hye Rim13ORCID,Sahagian Gary12ORCID,Baserga Susan J.7,Mazar Andrew5,Ferrer Marc3,Zheng Wei3ORCID,Shilatifard Ali6ORCID,Aubé Jeffrey1ORCID,Rudloff Udo4ORCID,Marugan Juan Jose3ORCID,Huang Sui2ORCID

Affiliation:

1. Specialized Chemistry Center, The University of Kansas, Lawrence, KS 66047, USA.

2. Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA.

3. NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA.

4. Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

5. Center for Developmental Therapeutics, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA.

6. Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

7. Departments of Molecular Biophysics and Biochemistry, Genetics, and Therapeutic Radiology, Yale University and Yale School of Medicine, New Haven, CT 06520, USA.

8. Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.

9. Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Fort Detrick, Frederick, MD 21702, USA.

10. Laboratory of Pathology, Center for Cancer Research, NIH, Bethesda, MD 20892, USA.

11. Electron Microscope Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.

12. Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.

13. Department of Human Genetics, Cancer Biology Graduate Program, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

A compound that reduces the prevalence of perinucleolar compartment in cancer cells inhibits metastasis in vivo.

Funder

NIH Office of the Director

V Foundation for Cancer Research

Robert H Lurie Comprehensive Cancer Center

NIH intramural

Translational Bridge Program Fellowship in Lymphoma Research

H Foundation

IDP

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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