Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species

Author:

Thompson Corbin G.1ORCID,Rosen Elias P.1ORCID,Prince Heather M. A.2,White Nicole1ORCID,Sykes Craig1,de la Cruz Gabriela3ORCID,Mathews Michelle3,Deleage Claire4ORCID,Estes Jacob D.45,Charlins Paige6,Mulder Leila R.6ORCID,Kovarova Martina3,Adamson Lourdes7,Arora Shifali2ORCID,Dellon Evan S.2ORCID,Peery Anne F.2,Shaheen Nicholas J.2ORCID,Gay Cynthia2,Muddiman David C.8ORCID,Akkina Ramesh6,Victor Garcia J.3,Luciw Paul7,Kashuba Angela D. M.1ORCID

Affiliation:

1. Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

2. School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

3. Division of Infectious Diseases, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

4. AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, USA.

5. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.

6. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.

7. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.

8. W.M. Keck FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, NC, USA.

Abstract

Imaging reveals that antiretroviral drugs are not distributed evenly in the mammalian gut, with potential implications for HIV replication.

Funder

National Institutes of Health

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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