Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Author:

Wang Yuxuan1ORCID,Li Lu2ORCID,Douville Christopher1ORCID,Cohen Joshua D.13ORCID,Yen Ting-Tai4ORCID,Kinde Isaac5,Sundfelt Karin6ORCID,Kjær Susanne K.78ORCID,Hruban Ralph H.9,Shih Ie-Ming9,Wang Tian-Li9,Kurman Robert J.9,Springer Simeon1,Ptak Janine1ORCID,Popoli Maria1,Schaefer Joy1ORCID,Silliman Natalie1ORCID,Dobbyn Lisa1ORCID,Tanner Edward J.4ORCID,Angarita Ana4,Lycke Maria6ORCID,Jochumsen Kirsten10ORCID,Afsari Bahman2,Danilova Ludmila2ORCID,Levine Douglas A.11ORCID,Jardon Kris12ORCID,Zeng Xing12ORCID,Arseneau Jocelyne12ORCID,Fu Lili12,Diaz Luis A.1ORCID,Karchin Rachel13ORCID,Tomasetti Cristian2ORCID,Kinzler Kenneth W.1ORCID,Vogelstein Bert114ORCID,Fader Amanda N.4ORCID,Gilbert Lucy12ORCID,Papadopoulos Nickolas1ORCID

Affiliation:

1. Ludwig Center for Cancer Genetics and Therapeutics, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2. Division of Biostatistics and Bioinformatics, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

5. PapGene Inc. Baltimore, MD 21211, USA.

6. Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg 405 30, Sweden.

7. Department of Obstetrics and Gynecology, Copenhagen University Hospital Rigshospitalet, Copenhagen 2100, Denmark.

8. Unit of Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen 2100, Denmark.

9. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

10. Department of Obstetrics and Gynecology, Odense University Hospital, Odense 5000, Denmark.

11. Department of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Centre, New York University Langone Medical Center, New York, NY 10016, USA.

12. Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, Oncology, and Pathology, McGill University and McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.

13. Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.

14. Howard Hughes Medical Institute, Baltimore, MD 21287, USA.

Abstract

Endometrial and ovarian cancers can be detected through the analysis of DNA from Pap test fluids, intrauterine samples, and plasma.

Funder

National Cancer Institute

John Templeton Foundation

United States Department of Defense

Swedish Cancer Foundation

Virginia and D.K. Ludwig Fund for Cancer Research

Sol Goldman Sequencing Facility at Johns Hopkins

Gray Foundation

Swim Across America

Novo Nordisk Foundation

Göteborg Medical Society

The Commonwealth Foundation

Conrad R. Hilton Foundation

the MERMAID Project

Royal Victoria Hospital Foundation

Carole Epstein Foundation

Doggone Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference57 articles.

1. Sensitivity and Specificity of the Pap Smear for Glandular Lesions of the Cervix and Endometrium

2. Significance of endometrial cells in the detection of endometrial carcinoma and its precursors;Ng A. B.;Acta Cytol.,1974

3. Clinical Significance of Atypical Glandular Cells on Cervical Cytology

4. Histologic follow-up results in 662 patients with Pap test findings of atypical glandular cells: Results from a large academic womens hospital laboratory employing sensitive screening methods

5. N. Howlader A. M. Noone M. Krapcho D. Miller K. Bishop S. F. Altekruse C. L. Kosary M. Yu J. Ruhl Z. Tatalovich A. Mariotto D. R. Lewis H. S. Chen E. J. Feuer K. A. Cronin SEER Cancer Statistics Review 1975–2014 (National Cancer Institute 2017).

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