Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase-Reference-Cited by-同舟云学术

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase

Published:2016-02-10 Issue:325 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Jarrett Rachael¹,Salio Mariolina¹,Lloyd-Lavery Antonia¹,Subramaniam Sumithra¹,Bourgeois Elvire²,Archer Charles¹,Cheung Ka Lun¹,Hardman Clare¹,Chandler David¹,Salimi Maryam¹,Gutowska-Owsiak Danuta¹,de la Serna Jorge Bernardino¹,Fallon Padraic G.³⁴⁵,Jolin Helen⁶,Mckenzie Andrew⁶,Dziembowski Andrzej⁷,Podobas Ewa Izabela⁷,Bal Wojciech⁷,Johnson David⁸,Moody D. Branch²,Cerundolo Vincenzo¹,Ogg Graham¹

Affiliation:

1. Medical Research Council (MRC) Human Immunology Unit, National Institute for Health Research Biomedical Research Centre, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

2. Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02114, USA.

3. Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.

4. Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James’s Hospital, Dublin 2, Ireland.

5. National Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin 12, Ireland.

6. MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

7. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.

8. Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Oxford University Hospitals National Health Service Trust, Oxford OX3 9DU, UK.

Abstract

Lack of the skin barrier protein filaggrin worsens atopic dermatitis by allergenic activation of CD1a-reactive T cells.

Funder

UK Medical Research Council (MRC)

National Institute for Health Research (NIHR)

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Burroughs Wellcome Fund

British Association of Dermatologists

British Skin Foundation

MRC Clinical Research Training Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference83 articles.

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3. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

4. Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease

5. Localisation of atopy and β subunit of high-affinity IgE receptor (Fc∈RI) on chromosome 11q

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