Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes-Reference-Cited by-同舟云学术

Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes

Published:2016-02-03 Issue:324 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Schiffer Joshua T.¹²³,Swan David A.²,Magaret Amalia²⁴,Corey Lawrence¹²⁴,Wald Anna¹²⁴⁵,Ossig Joachim⁶,Ruebsamen-Schaeff Helga⁶,Stoelben Susanne⁶,Timmler Burkhard⁶,Zimmermann Holger⁶,Melhem Murad R.⁷,Van Wart Scott A.⁷⁸,Rubino Christopher M.⁷⁸,Birkmann Alexander⁶

Affiliation:

1. Department of Medicine, University of Washington, Seattle, WA 98105, USA.

2. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

3. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. Department of Laboratory Medicine, University of Washington, Seattle, WA 98105, USA.

5. Department of Epidemiology, University of Washington, Seattle, WA 98105, USA.

6. AiCuris, Wuppertal D-42117, Germany.

7. Institute for Clinical Pharmacodynamics, Latham, NY 12307, USA.

8. School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.

Abstract

A mathematical model for antiviral clinical trials improves dose selection and understanding of drug-virus interaction.

Funder

National Institute of Health (NIH)

National Institute of Allergy and Infectious Diseases (NIAID)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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