Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5-Reference-Cited by-同舟云学术

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5

Published:2015-12-09 Issue:317 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Alard Jean-Eric¹,Ortega-Gomez Almudena¹,Wichapong Kanin²,Bongiovanni Dario³,Horckmans Michael¹,Megens Remco T. A.¹²,Leoni Giovanna¹,Ferraro Bartolo¹⁴,Rossaint Jan⁵,Paulin Nicole¹,Ng Judy³,Ippel Hans²,Suylen Dennis²,Hinkel Rabea¹³⁶,Blanchet Xavier¹,Gaillard Fanny⁷,D’Amico Michele⁴,von Hundelshausen Phillipp¹,Zarbock Alexander⁵,Scheiermann Christoph⁸,Hackeng Tilman M.²,Steffens Sabine¹⁶,Kupatt Christian³⁶,Nicolaes Gerry A. F.²,Weber Christian¹²⁶,Soehnlein Oliver¹⁶⁹

Affiliation:

1. Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, 80336 Munich, Germany.

2. Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, 6200 Maastricht, Netherlands.

3. Medizinische Klinik I, Technische Universität München, 81675 Munich, Germany.

4. Department of Experimental Medicine, University of Naples, 80138 Naples, Italy.

5. Department of Anesthesiology, University of Münster, 48149 Münster, Germany.

6. German Centre for Cardiovascular Research, partner site Munich Heart Alliance, 80336 Munich, Germany.

7. Roscoff Biological Station, Pierre et Marie Curie University, 29682 Paris, France.

8. Walter-Brendel-Center of Experimental Medicine, Ludwig Maximilians University Munich, 81377 Munich, Germany.

9. Department of Pathology, Academic Medical Center, 1105 Amsterdam, Netherlands.

Abstract

Disrupting the HNP1 and CCL5 heteromer between neutrophils and platelets blocks monocyte recruitment to inflammatory sites.

Funder

Alexander von Humboldt Foundation

European Research Council

ERC

German Research Foundation (DFG)

DFG

Else Kroner Fresenius Stiftung

Netherlands Organisation for Scientific Research (NWO)

NWO

Cyttron II

Cardiovascular Research Institute Maastricht

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference40 articles.

1. Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody.

2. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

3. Neutrophil secretion products pave the way for inflammatory monocytes

4. Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

5. Mechanisms underlying neutrophil-mediated monocyte recruitment

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