Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone-Reference-Cited by-同舟云学术

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

Published:2016-05-25 Issue:340 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Price Trevor T.¹,Burness Monika L.²,Sivan Ayelet³,Warner Matthew J.¹,Cheng Renee¹,Lee Clara H.¹,Olivere Lindsey¹,Comatas Karrie⁴,Magnani John⁵,Kim Lyerly H.⁴,Cheng Qing⁴,McCall Chad M.⁶,Sipkins Dorothy A.¹

Affiliation:

1. Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC 27707, USA.

2. Division of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

3. Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.

4. Department of Surgery, Duke University, Durham, NC 27707, USA.

5. GlycoMimetics Inc., Rockville, MD 20850, USA.

6. Department of Pathology, Duke University, Durham, NC 27707, USA.

Abstract

Breast cancer cells traffic to and from the peripheral blood within specific vascular niches, and this migration can be therapeutically targeted.

Funder

American Society of Clinical Oncology

University of Chicago Breast Cancer Specialized Program of Research Excellence

Duke Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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