Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity-Reference-Cited by-同舟云学术

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity

Published:2016-04-06 Issue:333 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Xu Jin-Chong¹²,Fan Jing¹²,Wang Xueqing¹²,Eacker Stephen M.¹²,Kam Tae-In¹²,Chen Li¹²,Yin Xiling¹²,Zhu Juehua¹²³,Chi Zhikai¹²,Jiang Haisong¹²,Chen Rong¹²,Dawson Ted M.¹²⁴⁵,Dawson Valina L.¹²⁴⁶

Affiliation:

1. Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.

4. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

5. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

6. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

A method to culture human cortical neurons that yielded a balanced network of excitatory and inhibitory neurons revealed that these cells die in a PARP-dependent manner after neurotoxic insult.

Funder

NIH/National Institute of Neurological Disorders and Stroke

NIH/National Institute on Drug Abuse

Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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