The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients-Reference-Cited by-同舟云学术

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients

Published:2016-11-02 Issue:363 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kennedy Matthew E.¹,Stamford Andrew W.²,Chen Xia¹,Cox Kathleen³,Cumming Jared N.²,Dockendorf Marissa F.³,Egan Michael⁴,Ereshefsky Larry⁵,Hodgson Robert A.¹,Hyde Lynn A.¹,Jhee Stanford⁵,Kleijn Huub J.³,Kuvelkar Reshma¹,Li Wei²,Mattson Britta A.⁶,Mei Hong³,Palcza John⁷,Scott Jack D.²,Tanen Michael⁸,Troyer Matthew D.⁹,Tseng Jack L.⁹,Stone Julie A.³,Parker Eric M.¹,Forman Mark S.⁹

Affiliation:

1. Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.

2. Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.

3. Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.

4. Department of Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA.

5. PAREXEL, Glendale, CA 91206, USA.

6. Department of Safety Assessment, Merck Research Laboratories, West Point, PA 19446, USA.

7. Department of Biostatistics, Merck Research Laboratories, Kenilworth, NJ 07033, USA.

8. Translational Biomarkers Department, Merck Research Laboratories, Kenilworth, NJ 07033, USA.

9. Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA.

Abstract

The BACE1 inhibitor verubecestat safely reduces β-amyloid deposition in rats, monkeys, healthy human subjects, and patients with Alzheimer’s disease.

Funder

Merck & Co. Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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