TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus-Reference-Cited by-同舟云学术

TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus

Published:2016-02-24 Issue:327 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Abt Michael C.¹,Buffie Charlie G.²,Sušac Bože¹,Becattini Simone¹,Carter Rebecca A.¹,Leiner Ingrid¹,Keith James W.¹,Artis David³,Osborne Lisa C.⁴,Pamer Eric G.¹²⁵

Affiliation:

1. Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.

4. Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

5. Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract

A synthetic TLR-7 agonist restores immune defenses to an antibiotic-resistant pathogen lost due to antibiotic use.

Funder

U.S. NIH

Irvington Institute Postdoctoral Fellowship of the Cancer Research Institute

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference54 articles.

1. Antibiotic Resistance Threats in the United States 2013 (Centers for Disease Control and Prevention Atlanta GA 2014).

2. The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

3. Diversity of the Human Intestinal Microbial Flora

4. Emergence and management of drug-resistant enterococcal infections

5. The rise of the Enterococcus: beyond vancomycin resistance

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