Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention-Reference-Cited by-同舟云学术

Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention

Published:2015-11-25 Issue:315 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Furlan Scott N.¹,Watkins Benjamin²,Tkachev Victor¹,Flynn Ryan³,Cooley Sarah³,Ramakrishnan Swetha²,Singh Karnail²,Giver Cindy²,Hamby Kelly²,Stempora Linda²,Garrett Aneesah²,Chen Jingyang¹,Betz Kayla M.¹,Ziegler Carly G. K.⁴,Tharp Gregory K.⁵,Bosinger Steven E.⁵,Promislow Daniel E. L.⁶,Miller Jeffrey S.³,Waller Edmund K.²,Blazar Bruce R.³,Kean Leslie S.¹

Affiliation:

1. Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, the University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle WA 98101, USA.

2. Emory University School of Medicine, Atlanta, GA 30322, USA.

3. Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.

4. Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

6. Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Abstract

Transcriptomic profiling of primate T cells during acute graft-versus-host disease reveals signaling pathways that when inhibited, ameliorate disease.

Funder

NIH

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Yerkes National Primate Research Center Base

Emory University Atlanta Clinical

Translational Science Institute Pilot

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference85 articles.