Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

Author:

Lynch Rebecca M.1,Boritz Eli1,Coates Emily E.1,DeZure Adam1,Madden Patrick1,Costner Pamela1,Enama Mary E.1,Plummer Sarah1,Holman Lasonji1,Hendel Cynthia S.1,Gordon Ingelise1,Casazza Joseph1,Conan-Cibotti Michelle1,Migueles Stephen A.2,Tressler Randall3,Bailer Robert T.1,McDermott Adrian1,Narpala Sandeep1,O’Dell Sijy1,Wolf Gideon1,Lifson Jeffrey D.4,Freemire Brandie A.4,Gorelick Robert J.4,Pandey Janardan P.5,Mohan Sarumathi5,Chomont Nicolas6,Fromentin Remi6,Chun Tae-Wook2,Fauci Anthony S.2,Schwartz Richard M.1,Koup Richard A.1,Douek Daniel C.1,Hu Zonghui7,Capparelli Edmund8,Graham Barney S.1,Mascola John R.1,Ledgerwood Julie E.1,

Affiliation:

1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

5. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

6. Department of Microbiology, Infectiology, and Immunology, Université de Montréal, Faculty of Medicine, and Centre de Recherche du CHUM (Centre hospitalier de l’Université de Montréal), Montreal, Quebec H2X 0A9, Canada.

7. Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

8. School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, CA 92110, USA.

Abstract

A single infusion with broadly neutralizing antibody VRC01 resulted in lowered plasma virus load in HIV-1–infected subjects.

Funder

NIH

National Cancer Institute/NIH

NIAID

Delaney AIDS Research Enterprise

VRC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference68 articles.

1. Defeating AIDS—advancing global health

2. HIV Monoclonal Antibodies: A New Opportunity to Further Reduce Mother-to-Child HIV Transmission

3. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

4. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

5. D. L. Bolton A. Pegu K. Wang K. McGinnis M. Nason K. Foulds V. Letukas S. D. Schmidt X. Chen J. P. Todd J. Lifson S. Rao N. L. Michael M. L. Robb J. R. Mascola R. A. Koup HIV-1 monoclonal antibodies suppress acute SHIV viremia and limit seeding of cell-associated viral reservoirs. J. Virol. JVI.02454-15 (2015).

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