The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia-Reference-Cited by-同舟云学术

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Published:2016-05-18 Issue:339 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Brumatti Gabriela¹²,Ma Chunyan¹²,Lalaoui Najoua¹²,Nguyen Nhu-Y³,Navarro Mario⁴,Tanzer Maria C.¹²,Richmond Jennifer⁵,Ghisi Margherita⁶,Salmon Jessica M.⁶,Silke Natasha¹²,Pomilio Giovanna³,Glaser Stefan P.¹²,de Valle Elisha⁷⁸,Gugasyan Raffi⁷⁸,Gurthridge Mark A.³,Condon Stephen M.⁹,Johnstone Ricky W.⁶,Lock Richard⁵,Salvesen Guy⁴,Wei Andrew³,Vaux David L.¹²,Ekert Paul G.¹²¹⁰,Silke John¹²

Affiliation:

1. Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia.

2. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.

3. Alfred Hospital and Monash University, Melbourne, Victoria 3004, Australia.

4. Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

5. Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2031, Australia.

6. Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.

7. Burnet Institute, Melbourne, Victoria 3004, Australia.

8. Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.

9. TetraLogic Pharmaceuticals Corporation, Malvern, PA 19355, USA.

10. Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Victoria 3052, Australia.

Abstract

The combination of a SMAC mimetic and a caspase inhibitor kills AML cells by inducing necroptosis.

Funder

Leukemia & Lymphoma Society

Specialized Center of Research

National Health and Medical Research Council

Association pour le Recherche contre le Cancer (ARC)

Australian Cancer Research Foundation

Victorian State Government Operational Infrastructure Support

NHMRC Independent Research Institutes Infrastructure Support Scheme

NIH

NHMRC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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