Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL-Reference-Cited by-同舟云学术

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL

Published:2016-05-18 Issue:339 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

McComb Scott¹,Aguadé-Gorgorió Júlia¹,Harder Lena¹,Marovca Blerim¹,Cario Gunnar²,Eckert Cornelia³,Schrappe Martin²,Stanulla Martin⁴,von Stackelberg Arend³,Bourquin Jean-Pierre¹,Bornhauser Beat C.¹

Affiliation:

1. Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.

2. Department of General Pediatrics, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

3. Department of Pediatric Oncology and Hematology, Charité Medical University Berlin, 13353 Berlin, Germany.

4. Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.

Abstract

SMAC mimetics simultaneously activate two different cell death pathways in treatment-resistant ALL.

Funder

Stiftung Kinderkrebsforschung Schweiz

Empiris Foundation

Human Hemato-Lymphatic Diseases of the University of Zurich

Swiss Cancer League

Novartis Foundation for Biomedical Research

Swiss National Science Foundation

Canadian Institutes for Health Research

Forschungskredit of the University of Zurich

Fondation Panacee

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. How I treat relapsed childhood acute lymphoblastic leukemia

2. How I treat acute lymphoblastic leukemia in older adolescents and young adults

3. Genomic Characterization of Childhood Acute Lymphoblastic Leukemia

4. Tumor resistance to apoptosis

5. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

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