Cord blood monocyte–derived inflammatory cytokines suppress IL-2 and induce nonclassic “T H 2-type” immunity associated with development of food allergy

Author:

Zhang Yuxia123,Collier Fiona45,Naselli Gaetano1,Saffery Richard26,Tang Mimi LK.26,Allen Katrina J.26,Ponsonby Anne-Louise26,Harrison Leonard C.12,Vuillermin Peter2456,

Affiliation:

1. Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

2. The University of Melbourne, Parkville, Victoria 3010, Australia.

3. Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.

4. Barwon Health, Geelong, Victoria 3220, Australia.

5. Deakin University, Geelong, Victoria 3216, Australia.

6. Murdoch Childrens Research Institute, Royal Children’s Hospital, Parkville, Victoria 3052, Australia.

Abstract

Infants who develop food allergy display hyperresponsive innate immunity at birth that promotes nonclassical T H 2 differentiation.

Funder

National Health and Medical Research Counci (NHMRC)l

National Health and Medical Research Counci (NHMRC)

National Health and Medical Research Council (NHMRC)

Juvenile Diabetes Research Foundation

Walter and Eliza Hall Institute Catalyst Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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