Targeting protein homeostasis in sporadic inclusion body myositis-Reference-Cited by-同舟云学术

Targeting protein homeostasis in sporadic inclusion body myositis

Published:2016-03-23 Issue:331 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ahmed Mhoriam¹²,Machado Pedro M.¹,Miller Adrian¹²,Spicer Charlotte¹²,Herbelin Laura³,He Jianghua⁴,Noel Janelle⁴,Wang Yunxia³,McVey April L.³,Pasnoor Mamatha³,Gallagher Philip⁵,Statland Jeffrey³,Lu Ching-Hua¹²,Kalmar Bernadett¹²,Brady Stefen¹,Sethi Huma⁶,Samandouras George⁶,Parton Matt¹,Holton Janice L.¹,Weston Anne⁷,Collinson Lucy⁷,Taylor J. Paul⁸,Schiavo Giampietro¹²,Hanna Michael G.¹,Barohn Richard J.³,Dimachkie Mazen M.³,Greensmith Linda¹²

Affiliation:

1. Medical Research Council (MRC) Centre for Neuromuscular Diseases, University College London (UCL) Institute of Neurology, Queen Square, London WC1N 3BG, UK.

2. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

3. Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 2012, Kansas City, KS 66160, USA.

4. Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

5. Department of Health, Sport, and Exercise Science, The University of Kansas, Lawrence, KS 66045–7567, USA.

6. Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, UCL Hospitals, Queen Square, London WC1N 3BG, UK.

7. The Francis Crick Institute, Lincoln’s Inn Fields Laboratory, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

8. Department of Cell & Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105–3678, USA.

Abstract

Augmenting the heat shock response with arimoclomol ameliorates pathology in cellular and animal models of inclusion body myositis.

Funder

Arthritis Research UK

MRC Centre for Neuromuscular Diseases

Kansas University Neurology Department Ziegler

Kansas University GCRC CReFF (General Clinical Research Centre Clinical Research Feasibility Funding)

Wellcome Trust

Brain Research Trust

Rosetrees Trust

The Stoneygate Trust

European Community's Seventh Framework Programme

Cancer Research UK

MRC

UK Biotechnology and Biological Sciences Research Council

EPSRC (Engineering and Physical Sciences Research Council)

National Institute for Health Research (NIHR)

Rare Diseases Translational Research Collaboration (RD TRC)

NIHR University College London Hospitals (UCLH)

Biomedical Research Centre (BRC)

UK National Health Service (NHS)

NIHR

Department of Health

Institutional Clinical and Translational Science Award

NIH/NCATS (National Center for Advancing Translational Sciences)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

1. Inclusion Body Myositis

2. Update in inclusion body myositis

3. Inclusion body myositis: Clinical and pathological boundaries

4. Evaluation and treatment of inflammatory myopathies

5. A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities

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