Two-mAb cocktail protects macaques against the Makona variant of Ebola virus

Author:

Qiu Xiangguo12,Audet Jonathan1,Lv Ming3,He Shihua12,Wong Gary2,Wei Haiyan24,Luo Longlong3,Fernando Lisa2,Kroeker Andrea12,Bovendo Hugues Fausther2,Bello Alexander2,Li Feng5,Ye Pei5,Jacobs Michael6,Ippolito Giuseppe7,Saphire Erica Ollmann89,Bi Shengli10,Shen Beifen3,Gao George F.11,Zeitlin Larry12,Feng Jiannan3,Zhang Boyan5,Kobinger Gary P.121314

Affiliation:

1. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

2. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

3. Laboratory of Immunology, Institute of Basic Medical Sciences, Taiping Road #27, Beijing 100850, China.

4. Institute of Infectious Disease, Henan Center for Disease Control and Prevention, Zhengzhou, Henan 450012, China.

5. Beijing Mabworks Biotech Co. Ltd., No. 99, Kechuang 14th Street, Economic-Technological Development Area, Beijing 101111, China.

6. Royal Free London NHS (National Health Service) Foundation Trust, Pond Street, London NW3 2QG, UK.

7. National Institute for Infectious Diseases “Lazzaro Spallanzani,” Rome 00149, Italy.

8. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

9. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

10. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

11. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China.

12. Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.

13. Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.

14. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.

Abstract

A two–monoclonal antibody cocktail protects nonhuman primates against Ebola virus 3 days after lethal exposure.

Funder

Canadian Safety and Security Program

NIH

China National Key Subject of Drug Innovation

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference24 articles.

1. Centers for Disease Control and Prevention Outbreaks Chronology: Ebola Virus Disease (available at www.cdc.gov/vhf/ebola/outbreaks/history/chronology.html) (2015).

2. Centers for Disease Control and Prevention Chronology of Marburg Hemorrhagic Fever Outbreaks Marburg hemorrhagic fever (Marburg HF) (available at www.cdc.gov/vhf/marburg/resources/outbreak-table.html) (2014).

3. Emergence of Zaire Ebola Virus Disease in Guinea

4. Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014

5. Ebola virus disease in health care workers—Sierra Leone 2014;Kilmarx P. H.;MMWR Morb. Mortal. Wkly. Rep.,2014

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