Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence-Reference-Cited by-同舟云学术

Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence

Published:2016-04-13 Issue:334 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Balko Justin M.¹²³,Schwarz Luis J.¹,Luo Na¹,Estrada Mónica V.³⁴,Giltnane Jennifer M.³⁴,Dávila-González Daniel⁵,Wang Kai⁶,Sánchez Violeta¹,Dean Phillip T.¹,Combs Susan E.⁷,Hicks Donna²,Pinto Joseph A.⁸,Landis Melissa D.⁵,Doimi Franco D.⁹,Yelensky Roman⁶,Miller Vincent A.⁶,Stephens Phillip J.⁶,Rimm David L.⁷,Gómez Henry⁹,Chang Jenny C.⁵,Sanders Melinda E.³⁴,Cook Rebecca S.²³,Arteaga Carlos L.¹²³

Affiliation:

1. Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

2. Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.

3. Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA.

4. Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.

5. Houston Methodist Cancer Center, Houston, TX 77030, USA.

6. Foundation Medicine, Cambridge, MA 02142, USA.

7. Departments of Pathology and Medicine, Yale University, New Haven, CT 06520, USA.

8. Oncosalud, Lima 41, Perú.

9. Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima 34, Perú.

Abstract

JAK2 amplification decreases survival in triple-negative breast cancer but can be targeted with JAK2-specific inhibitors.