Immune history profoundly affects broadly protective B cell responses to influenza

Author:

Andrews Sarah F.1,Huang Yunping1,Kaur Kaval12,Popova Lyubov I.1,Ho Irvin Y.1,Pauli Noel T.12,Dunand Carole J. Henry1,Taylor William M.1,Lim Samuel1,Huang Min1,Qu Xinyan1,Lee Jane-Hwei1,Salgado-Ferrer Marlene1,Krammer Florian3,Palese Peter34,Wrammert Jens5,Ahmed Rafi5,Wilson Patrick C.12

Affiliation:

1. Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA.

2. Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA.

3. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

4. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

5. Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

The quality of the B cell response to influenza vaccination is dependent on the preexisting memory B cell repertoire.

Funder

NIH

National Institute of Allergy and Infectious Diseases

Austrian Science Fund

CRIP (Center for Research on Influenza Pathogenesis)

Center of Excellence for Influenza Research and Surveillance

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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