Immune history profoundly affects broadly protective B cell responses to influenza-Reference-Cited by-同舟云学术

Immune history profoundly affects broadly protective B cell responses to influenza

Published:2015-12-02 Issue:316 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Andrews Sarah F.¹,Huang Yunping¹,Kaur Kaval¹²,Popova Lyubov I.¹,Ho Irvin Y.¹,Pauli Noel T.¹²,Dunand Carole J. Henry¹,Taylor William M.¹,Lim Samuel¹,Huang Min¹,Qu Xinyan¹,Lee Jane-Hwei¹,Salgado-Ferrer Marlene¹,Krammer Florian³,Palese Peter³⁴,Wrammert Jens⁵,Ahmed Rafi⁵,Wilson Patrick C.¹²

Affiliation:

1. Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA.

2. Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA.

3. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

4. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

5. Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

The quality of the B cell response to influenza vaccination is dependent on the preexisting memory B cell repertoire.

Funder

NIH

National Institute of Allergy and Infectious Diseases

Austrian Science Fund

CRIP (Center for Research on Influenza Pathogenesis)

Center of Excellence for Influenza Research and Surveillance