Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts-Reference-Cited by-同舟云学术

Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts

Published:2016-03-16 Issue:330 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Uluçkan Özge¹,Jimenez Maria¹,Karbach Susanne²³,Jeschke Anke⁴,Graña Osvaldo⁵,Keller Johannes⁴,Busse Björn⁴,Croxford Andrew L.³,Finzel Stephanie⁶,Koenders Marije⁷,van den Berg Wim⁷,Schinke Thorsten⁴,Amling Michael⁴,Waisman Ari³,Schett Georg⁶,Wagner Erwin F.¹

Affiliation:

1. Cancer Cell Biology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

2. Center for Cardiology—Cardiology 1, University Medical Center, D-55131 Mainz, Germany.

3. Institute of Molecular Medicine, University of Mainz, D-55131 Mainz, Germany.

4. Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

5. Bioinformatics Unit, Biotechnology Department, Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain.

6. Department of Internal Medicine 3, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

7. Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6525 Nijmegen, Netherlands.

Abstract

Skin inflammation inhibits bone formation through IL-17A.

Funder

European Molecular Biology Organization Long-Term Fellowship

ECTS/AMGEN Bone Biology Fellowship

Ministry of Economy and Competitiveness

Margarete Waitz-Stiftung

Stiftung Mainzer Herz

Collaborative Research Centres (SFB)

Banco Bilbao Vizcaya Argentaria (BBVA) Foundation

European Research Council

Deutsche Forschungsgemeinschaft