TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci-Reference-Cited by-同舟云学术

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Published:2016-03-09 Issue:329 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lee Sang Ho¹,Wang Hao¹,Labroli Marc²,Koseoglu Sandra¹,Zuck Paul²,Mayhood Todd¹,Gill Charles¹,Mann Paul¹,Sher Xinwei³,Ha Sookhee¹,Yang Shu-Wei¹,Mandal Mihir¹,Yang Christine¹,Liang Lianzhu¹,Tan Zheng¹,Tawa Paul¹,Hou Yan¹,Kuvelkar Reshma¹,DeVito Kristine¹,Wen Xiujuan¹,Xiao Jing¹,Batchlett Michelle²,Balibar Carl J.¹,Liu Jenny¹,Xiao Jianying¹,Murgolo Nicholas¹,Garlisi Charles G.¹,Sheth Payal R.¹,Flattery Amy¹,Su Jing¹,Tan Christopher¹,Roemer Terry¹

Affiliation:

1. Merck Research Laboratories, Kenilworth, NJ 07033, USA.

2. Merck Research Laboratories, West Point, PA 19486, USA.

3. Merck Research Laboratories, Boston, MA 02115, USA.

Abstract

New inhibitors of wall teichoic acid biosynthesis restore susceptibility of drug-resistant staphylococci to β-lactam antibiotics.

Funder

Merck & Co. Inc.

Merck Research Laboratory (MRL)

Publisher

American Association for the Advancement of Science (AAAS)

Subject