A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

Author:

Ryan Katie J.1234ORCID,White Charles C.124,Patel Kruti1234ORCID,Xu Jishu124ORCID,Olah Marta45,Replogle Joseph M.1234,Frangieh Michael124,Cimpean Maria124ORCID,Winn Phoebe124,McHenry Allison124,Kaskow Belinda J.1234,Chan Gail1234,Cuerdon Nicole1234ORCID,Bennett David A.6ORCID,Boyd Justin D.13ORCID,Imitola Jaime7ORCID,Elyaman Wassim45,De Jager Philip L.45ORCID,Bradshaw Elizabeth M.45ORCID

Affiliation:

1. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, NRB168, Boston, MA 02115, USA.

3. Harvard Medical School, Boston, MA 02115, USA.

4. Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.

5. Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA.

6. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.

7. Laboratory of Neural Stem Cells and Functional Neurogenetics, Departments of Neurology and Neuroscience, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA.

Abstract

A microglial-like cellular model can be used to identify functional consequences of genetic variants associated with neurodegenerative disease.

Funder

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Alzheimer’s Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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