Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data-Reference-Cited by-同舟云学术

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data

Published:2018-04-04 Issue:435 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rifat Dalin¹^ORCID,Prideaux Brendan²^ORCID,Savic Radojka M.³,Urbanowski Michael E.¹,Parsons Teresa L.¹,Luna Brian⁴^ORCID,Marzinke Mark A.¹^ORCID,Ordonez Alvaro A.¹^ORCID,DeMarco Vincent P.¹^ORCID,Jain Sanjay K.¹,Dartois Veronique²^ORCID,Bishai William R.¹^ORCID,Dooley Kelly E.¹^ORCID

Affiliation:

1. Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Rutgers New Jersey Medical School, Public Health Research Institute, Newark, NJ 07103, USA.

3. Department of Bioengineering, University of California at San Francisco School of Pharmacy, San Francisco, CA 94117, USA.

4. Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA

Abstract

A rabbit model of pulmonary cavitary tuberculosis helps to explain phase 2 clinical trial results for the rifamycin class of TB drugs.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference28 articles.

1. WHO Global Tuberculosis Report 2017 (World Health Organization); www.who.int/tb/publications/global_report/gtbr2017_main_text.pdf.

2. The association between sterilizing activity and drug distribution into tuberculosis lesions

3. Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase

4. Daily Rifapentine for Treatment of Pulmonary Tuberculosis. A Randomized, Dose-Ranging Trial

5. Substitution of Rifapentine for Rifampin During Intensive Phase Treatment of Pulmonary Tuberculosis: Study 29 of the Tuberculosis Trials Consortium

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