The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

Author:

Micheletti Rudi1ORCID,Plaisance Isabelle1,Abraham Brian J.2ORCID,Sarre Alexandre3,Ting Ching-Chia1,Alexanian Michael1,Maric Daniel1,Maison Damien1,Nemir Mohamed1,Young Richard A.24,Schroen Blanche5,González Arantxa67ORCID,Ounzain Samir1,Pedrazzini Thierry1ORCID

Affiliation:

1. Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School, Lausanne, Switzerland.

2. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

3. Cardiovascular Assessment Facility, University of Lausanne, Lausanne, Switzerland.

4. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Center for Heart Failure Research, Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands.

6. Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

7. National Institute of Health Carlos III, Madrid, Spain.

Abstract

A super-enhancer–associated long noncoding RNA, Wisper , controls cardiac fibrosis and pathological remodeling in the damaged heart.

Funder

Swiss National Science Foundation

Ministry of Economy and Competitiveness, Spain

Hope Funds for Cancer Research

The Netherlands Organization for Scientific Research

The Netherlands Heart Foundation

European Union

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference65 articles.

1. The Biological Basis for Cardiac Repair After Myocardial Infarction

2. Pathophysiology of Myocardial Infarction

3. Heart disease and stroke statistics—2016 update: A report from the American Heart Association;Writing Group Members;Circulation,2016

4. Integrating the Myocardial Matrix Into Heart Failure Recognition and Management

5. Therapeutic Targets in Heart Failure

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