Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage-Reference-Cited by-同舟云学术

Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage

Published:2017-01-18 Issue:373 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lima e Silva Raquel¹²,Kanan Yogita¹²,Mirando Adam C.³,Kim Jayoung³⁴,Shmueli Ron B.³⁴,Lorenc Valeria E.¹²,Fortmann Seth D.¹²,Sciamanna Jason¹²,Pandey Niranjan B.³⁵,Green Jordan J.¹³⁴⁶,Popel Aleksander S.³,Campochiaro Peter A.¹²

Affiliation:

1. Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

5. AsclepiX Therapeutics, LLC, Baltimore, MD 21211, USA.

6. Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

An integrin-binding peptide derived from collagen IV prevents ligand-induced activation of multiple tyrosine kinase receptors and strongly suppresses ocular neovascularization and vascular leakage.

Funder

Edward N. and Della L. Thome Memorial Foundation

NIH NEI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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4. A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells

5. Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide

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