An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products

Author:

de los Reyes Jiménez Marta1ORCID,Lechner Antonie1ORCID,Alessandrini Francesca1,Bohnacker Sina1ORCID,Schindela Sonja1,Trompette Aurélien2ORCID,Haimerl Pascal1,Thomas Dominique3ORCID,Henkel Fiona1,Mourão André4ORCID,Geerlof Arie4,da Costa Clarissa Prazeres5,Chaker Adam M.6ORCID,Brüne Bernhard7ORCID,Nüsing Rolf7,Jakobsson Per-Johan8ORCID,Nockher Wolfgang A.9ORCID,Feige Matthias J.10ORCID,Haslbeck Martin11ORCID,Ohnmacht Caspar1,Marsland Benjamin J.12,Voehringer David13ORCID,Harris Nicola L.12ORCID,Schmidt-Weber Carsten B.114,Esser-von Bieren Julia1ORCID

Affiliation:

1. Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, 80802 Munich, Germany.

2. Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, Centre Hospitalier Universitaire Vaudois, 1066 Epalinges, Switzerland.

3. Institute of Clinical Pharmacology, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany.

4. Protein Expression and Purification Facility (PEPF), Institute of Structural Biology, Helmholtz Center Munich, Germany.

5. Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany.

6. Department of Otolaryngology, Allergy Section, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

7. Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany.

8. Rheumatology Unit, Department of Medicine, Karolinska Institute Stockholm, 171 76 Stockholm, Sweden.

9. Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps-University Marburg, 35043 Marburg, Germany.

10. Center for Integrated Protein Science Munich at the Department of Chemistry and Institute for Advanced Study, Technical University of Munich, 85748 Garching, Germany.

11. Department of Chemistry, Technical University of Munich, 85748 Garching, Germany.

12. Department of Immunology and Pathology, Central Clinical School, Monash University, The Alfred Centre, Melbourne, VIC 3004, Australia.

13. Department of Infection Biology, University Hospital Center, Friedrich-Alexander University, Erlangen-Nuremberg, Germany.

14. Member of the German Center of Lung Research (DZL).

Abstract

A helminth larval extract and its component Hpb glutamate dehydrogenase induce an anti-inflammatory mediator switch to suppress type-2 inflammation.

Funder

Deutsche Forschungsgemeinschaft

Else Kröner-Fresenius-Stiftung

Fritz Thyssen Stiftung

Helmholtz Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3