Gene therapy delivering a paraoxonase 1 variant offers long-term prophylactic protection against nerve agents in mice-Reference-Cited by-同舟云学术

Gene therapy delivering a paraoxonase 1 variant offers long-term prophylactic protection against nerve agents in mice

Published:2020-01-22 Issue:527 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Betapudi Venkaiah¹^ORCID,Goswami Reena¹^ORCID,Silayeva Liliya¹,Doctor Deborah M.¹,Chilukuri Nageswararao¹^ORCID

Affiliation:

1. Medical Toxicology Research Division, Biochemistry & Physiology Department, Agent Mitigation, United States Army Medical Research Institute of Chemical Defense, 8350 Ricketts Point Road, Aberdeen Proving Ground, MD 21010-5400, USA.

Abstract

Paraoxonase 1 variant IF-11 offers long-term prophylactic protection against chemical warfare nerve agents in mice.

Funder

Defense Threat Reduction Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

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5. Advice on assistance and protection from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents;Timperley C. M.;Toxicology,2019

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