Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys-Reference-Cited by-同舟云学术

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Published:2020-05-27 Issue:545 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kariolis Mihalis S.¹^ORCID,Wells Robert C.¹^ORCID,Getz Jennifer A.¹^ORCID,Kwan Wanda¹,Mahon Cathal S.¹^ORCID,Tong Raymond¹^ORCID,Kim Do Jin¹^ORCID,Srivastava Ankita¹^ORCID,Bedard Catherine¹^ORCID,Henne Kirk R.¹^ORCID,Giese Tina¹,Assimon Victoria A.¹,Chen Xiaocheng¹^ORCID,Zhang Yin¹,Solanoy Hilda¹,Jenkins Katherine¹^ORCID,Sanchez Pascal E.¹,Kane Lesley¹^ORCID,Miyamoto Takashi¹,Chew Kylie S.¹^ORCID,Pizzo Michelle E.¹^ORCID,Liang Nicholas¹^ORCID,Calvert Meredith E. K.¹^ORCID,DeVos Sarah L.¹,Baskaran Sulochanadevi¹,Hall Sejal¹^ORCID,Sweeney Zachary K.¹^ORCID,Thorne Robert G.¹^ORCID,Watts Ryan J.¹^ORCID,Dennis Mark S.¹^ORCID,Silverman Adam P.¹^ORCID,Zuchero Y. Joy Yu¹^ORCID

Affiliation:

1. Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, CA 94080, USA.

Abstract

Engineering human IgG1 Fc binding to a brain endothelial cell–enriched receptor allows enhanced brain exposure of biotherapeutics in multiple species.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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