siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice-Reference-Cited by-同舟云学术

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

Published:2020-07-22 Issue:553 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tao Wei¹^ORCID,Yurdagul Arif²^ORCID,Kong Na¹^ORCID,Li Wenliang¹,Wang Xiaobo²,Doran Amanda C.²^ORCID,Feng Chan¹,Wang Junqing¹^ORCID,Islam Mohammad Ariful¹^ORCID,Farokhzad Omid C.¹^ORCID,Tabas Ira²³⁴^ORCID,Shi Jinjun¹^ORCID

Affiliation:

1. Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.

3. Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.

4. Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Abstract

Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease.

Funder

National Institutes of Health

Brigham and Women’s Hospital

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. Macrophages in the Pathogenesis of Atherosclerosis

2. The promises and pitfalls of RNA-interference-based therapeutics

3. Knocking down barriers: advances in siRNA delivery

4. Non-viral vectors for gene-based therapy

5. Delivery materials for siRNA therapeutics

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