A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles

Author:

Claesen Jan1ORCID,Spagnolo Jennifer B.23,Ramos Stephany Flores2ORCID,Kurita Kenji L.4ORCID,Byrd Allyson L.5ORCID,Aksenov Alexander A.6ORCID,Melnik Alexey V.6ORCID,Wong Weng R.7ORCID,Wang Shuo8ORCID,Hernandez Ryan D.79ORCID,Donia Mohamed S.10ORCID,Dorrestein Pieter C.6ORCID,Kong Heidi H.11ORCID,Segre Julia A.5ORCID,Linington Roger G.4ORCID,Fischbach Michael A.12ORCID,Lemon Katherine P.2131415ORCID

Affiliation:

1. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

2. Microbiology, Forsyth Institute, Cambridge, MA 02142, USA.

3. Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA.

4. Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.

5. Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

6. Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.

7. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.

8. Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540, USA.

9. Department of Human Genetics, McGill University and Genome Quebec Innovation Center, Montreal, QC H3A 0C7, Canada.

10. Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.

11. Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

12. Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.

13. Division of Infectious Diseases, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

14. Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.

15. Section of Infectious Diseases, Department of Pediatrics, Texas Children’s Hospital and Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Cutimycin, a thiopeptide antibiotic produced by the skin commensal Cutibacterium acnes , reduces Staphylococcus colonization of human skin hair follicles.

Funder

Howard Hughes Medical Institute

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

National Center for Complementary and Alternative Medicine

Burroughs Wellcome Fund

Natural Sciences and Engineering Research Council of Canada

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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