Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology

Author:

Pan Ming-Kai12345ORCID,Li Yong-Shi6ORCID,Wong Shi-Bing67,Ni Chun-Lun6ORCID,Wang Yi-Mei5,Liu Wen-Chuan12,Lu Liang-Yin3ORCID,Lee Jye-Chang4,Cortes Etty P.8ORCID,Vonsattel Jean-Paul G.8,Sun Qian910ORCID,Louis Elan D.1112ORCID,Faust Phyllis L.8,Kuo Sheng-Han613ORCID

Affiliation:

1. Department of Medical Research, National Taiwan University Hospital, Taipei City 10002, Taiwan.

2. Institute of Pharmacology, College of Medicine, National Taiwan University Hospital, Taipei City 10051, Taiwan.

3. Neurobiology and Cognitive Science Center, National Taiwan University, Taipei City 10051, Taiwan.

4. Molecular Imaging Center, National Taiwan University, Taipei City 10051, Taiwan.

5. Department of Neurology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan.

6. Department of Neurology, Columbia University, New York, NY 10032, USA.

7. Department of Pediatrics, Taipei Tzu Chi Hospital, Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.

8. Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

9. Department of Neuroscience, Columbia University, New York, NY 10032, USA.

10. Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44016, USA.

11. Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT 06519, USA.

12. Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT 06510, USA.

13. Initiative of Columbia Ataxia and Tremor, New York, NY 10032, USA.

Abstract

Excessive cerebellar oscillations, resulting from GluRδ2-dependent pruning deficits of climbing fiber–to–Purkinje cell synapses, drive tremor.

Funder

National Institutes of Health

Ministry of Science and Technology, Taiwan

National Taiwan University Hospital

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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