Na v 1.7 target modulation and efficacy can be measured in nonhuman primate assays-Reference-Cited by-同舟云学术

Na v 1.7 target modulation and efficacy can be measured in nonhuman primate assays

Published:2021-05-19 Issue:594 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kraus Richard L.¹^ORCID,Zhao Fuqiang¹^ORCID,Pall Parul S.¹^ORCID,Zhou Dan¹,Vardigan Joshua D.¹^ORCID,Danziger Andrew¹,Li Yuxing¹,Daley Christopher¹,Ballard Jeanine E.¹^ORCID,Clements Michelle K.¹^ORCID,Klein Rebecca M.¹,Holahan Marie A.¹^ORCID,Greshock Thomas J.¹^ORCID,Kim Ronald M.¹,Layton Mark E.¹,Burgey Christopher S.¹^ORCID,Serra Jordi²,Henze Darrell A.¹^ORCID,Houghton Andrea K.¹^ORCID

Affiliation:

1. Merck & Co. Inc., WP-14, 770 Sumneytown Pike, P.O. Box 4, West Point, PA 19486, USA.

2. Department of Clinical Neurophysiology, Ruskin Wing, King’s College Hospital, Denmark Hill, London SE5 9RS, UK.

Abstract

Rhesus C-fiber microneurography, heat responsivity, and olfactory fMRI can be used as translatable biomarkers of Na v 1.7 target modulation.

Funder

Merck Sharp and Dohme

University of South Alabama

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine