Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis

Author:

Panizzi Peter1ORCID,Krohn-Grimberghe Marvin23ORCID,Keliher Edmund2ORCID,Ye Yu-Xiang2,Grune Jana2,Frodermann Vanessa2ORCID,Sun Yuan2ORCID,Muse Charlotte G.1ORCID,Bushey Kaitlyn4,Iwamoto Yoshiko2,van Leent Mandy M. T.5ORCID,Meerwaldt Anu5ORCID,Toner Yohana C.5ORCID,Munitz Jazz5ORCID,Maier Alexander5,Soultanidis Georgios5ORCID,Calcagno Claudia5,Pérez-Medina Carlos56ORCID,Carlucci Giuseppe7,Riddell Kay P.8,Barney Sharron9,Horne Glenn9,Anderson Brian10ORCID,Maddur-Appajaiah Ashoka11,Verhamme Ingrid M.11,Bock Paul E.11,Wojtkiewicz Gregory R.2ORCID,Courties Gabriel2ORCID,Swirski Filip K.2,Church William R.4,Walz Paul H.8,Tillson D. Michael9,Mulder Willem J. M.51213ORCID,Nahrendorf Matthias21415ORCID

Affiliation:

1. Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA.

2. Center for Systems Biology and Department of Radiology, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, MA 02114, USA.

3. University Heart Center Freiburg, 79106 Freiburg, Germany.

4. Green Mountain Antibodies, Burlington, VT 05401, USA.

5. Biomedical Engineering and Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

6. Centro Nacional de Investigaciones Cardivasculares, 28029 Madrid, Spain.

7. Bernard and Irene Schwarz Center for Biomedical Imaging, New York University, New York, NY 10016, USA.

8. Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.

9. Department of Clinical Science, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.

10. Swine Research and Education Center, Department of Animal Sciences, Auburn University, Auburn, AL 36849, USA.

11. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212, USA.

12. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

13. Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, Netherlands

14. Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

15. Department of Internal Medicine I, University Hospital Würzburg, 97080 Würzburg, Germany.

Abstract

Multimodal intravital microscopy and PET imaging of S. aureus endocarditis can monitor adjuvant immunotherapy in mice and pigs.

Funder

NHLBI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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