Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β-Reference-Cited by-同舟云学术

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Published:2020-01-08 Issue:525 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Metelli Alessandra¹^ORCID,Wu Bill X.²,Riesenberg Brian²,Guglietta Silvia¹^ORCID,Huck John D.³,Mills Catherine¹^ORCID,Li Anqi²,Rachidi Saleh¹^ORCID,Krieg Carsten¹^ORCID,Rubinstein Mark P.¹⁴^ORCID,Gewirth Daniel T.³,Sun Shaoli⁵,Lilly Michael B.⁶,Wahlquist Amy H.⁷,Carbone David P.²⁸^ORCID,Yang Yiping²⁹,Liu Bei¹^ORCID,Li Zihai¹²⁸^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

2. Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

3. Hauptman Woodward Medical Research Institute, Buffalo, NY 14203, USA.

4. Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

5. Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

6. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

7. Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.

8. Division of Medical Oncology, The Ohio State University, Columbus, OH 43210, USA.

9. Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH 43210, USA.

Abstract

Proteolysis of platelet-bound GARP by thrombin liberates active TGF-β and contributes to cancer immune evasion in the tumor microenvironment.

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference67 articles.

1. A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells

2. Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

3. Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

4. Thrombin inhibition and cyclophosphamide synergistically block tumor progression and metastasis

5. TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

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