Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

Author:

Ooft Salo N.12ORCID,Weeber Fleur12ORCID,Dijkstra Krijn K.12ORCID,McLean Chelsea M.12ORCID,Kaing Sovann12,van Werkhoven Erik3ORCID,Schipper Luuk12,Hoes Louisa12,Vis Daniel J.24,van de Haar Joris124ORCID,Prevoo Warner5,Snaebjornsson Petur6ORCID,van der Velden Daphne12ORCID,Klein Michelle12ORCID,Chalabi Myriam1ORCID,Boot Henk7,van Leerdam Monique7ORCID,Bloemendal Haiko J.8,Beerepoot Laurens V.9,Wessels Lodewyk2410,Cuppen Edwin21112,Clevers Hans21314ORCID,Voest Emile E.127ORCID

Affiliation:

1. Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

2. Oncode Institute, 3521 AL Utrecht, Netherlands.

3. Department of Biometrics, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

4. Department of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

5. Department of Radiology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

6. Department of Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

7. Department of Gastrointestinal Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

8. Department of Internal Medicine/Oncology, Radboud University Medical Center Nijmegen, 6525 GA Nijmegen, Netherlands.

9. Department of Internal Medicine, Elisabeth-TweeSteden Hospital, 5042 AD Tilburg, Netherlands.

10. Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, 2628 CD Delft, Netherlands.

11. Division Biomedical Genetics, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, Netherlands.

12. Hartwig Medical Foundation, 1098 XH Amsterdam, Netherlands.

13. Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, 3584 CT Utrecht, Netherlands.

14. Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, Netherlands.

Abstract

Tumor organoids from individual patients with metastatic colorectal cancer can help predict response to irinotecan with or without 5-fluorouracil.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

KWF Kankerbestrijding

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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