Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction

Author:

Thavapalachandran Sujitha12ORCID,Grieve Stuart M.3ORCID,Hume Robert D.1,Le Thi Yen Loan1ORCID,Raguram Kalyan1ORCID,Hudson James E.4,Pouliopoulos Jim2,Figtree Gemma A.5,Dye Rafael P.5ORCID,Barry Anthony M.2ORCID,Brown Paula2,Lu Juntang2,Coffey Sean56ORCID,Kesteven Scott H.7,Mills Richard J.4,Rashid Fairooj N.1,Taran Elena89ORCID,Kovoor Pramesh2,Thomas Liza2,Denniss Alan Robert2,Kizana Eddy12,Asli Naisana S.71011ORCID,Xaymardan Munira7,Feneley Michael P.712,Graham Robert M.712,Harvey Richard P.71213ORCID,Chong James J. H.12ORCID

Affiliation:

1. Centre for Heart Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.

2. Department of Cardiology, Westmead Hospital, Westmead, NSW 2145, Australia.

3. Sydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.

4. QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.

5. Kolling Institute of Medical Research, The University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.

6. Department of Medicine, Dunedin School of Medicine, Dunedin Hospital, Dunedin 9016, New Zealand.

7. Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.

8. Australian National Fabrication Facility–Queensland Node, The University of Queensland, St. Lucia, QLD 4072, Australia.

9. School of Chemical Engineering, University of Melbourne, VIC 3010, Australia.

10. Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia.

11. Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.

12. St. Vincent’s Clinical School, UNSW Sydney, Kensington, NSW 2052, Australia.

13. School of Biotechnology and Biomolecular Science, UNSW Sydney, Kensington, NSW 2052, Australia.

Abstract

Recombinant human platelet-derived growth factor-AB improves cardiac function and survival after myocardial infarction in a porcine model.

Funder

Heart Research Australia

National Health and Medical Research Council

National Heart Foundation of Australia

Sydney Medical School Foundation

Westmead Medical Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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