High-dose vitamin C enhances cancer immunotherapy

Author:

Magrì Alessandro12ORCID,Germano Giovanni12ORCID,Lorenzato Annalisa12ORCID,Lamba Simona2ORCID,Chilà Rosaria13,Montone Monica2ORCID,Amodio Vito12ORCID,Ceruti Tommaso4,Sassi Francesco2,Arena Sabrina12ORCID,Abrignani Sergio56ORCID,D’Incalci Maurizio4ORCID,Zucchetti Massimo4ORCID,Di Nicolantonio Federica12ORCID,Bardelli Alberto12ORCID

Affiliation:

1. Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.

2. Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.

3. IFOM, The FIRC Institute of Molecular Oncology, 20139 Milan, Italy.

4. Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.

5. Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’, 20122 Milan, Italy.

6. Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.

Abstract

Vitamin C promotes anticancer adaptive immunity and enhances efficacy of immune checkpoint therapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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