Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia-Reference-Cited by-同舟云学术

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia

Published:2021-08-04 Issue:605 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sartori Roberta¹²³^ORCID,Hagg Adam¹⁴⁵^ORCID,Zampieri Sandra³⁶⁷^ORCID,Armani Andrea²³^ORCID,Winbanks Catherine E.¹,Viana Laís R.⁴⁸^ORCID,Haidar Mouna⁹,Watt Kevin I.¹⁴^ORCID,Qian Hongwei¹⁴^ORCID,Pezzini Camilla²³,Zanganeh Pardis⁹^ORCID,Turner Bradley J.⁹^ORCID,Larsson Anna¹⁰,Zanchettin Gianpietro⁶^ORCID,Pierobon Elisa S.⁶^ORCID,Moletta Lucia⁶^ORCID,Valmasoni Michele⁶^ORCID,Ponzoni Alberto¹¹,Attar Shady¹²^ORCID,Da Dalt Gianfranco⁶^ORCID,Sperti Cosimo⁶^ORCID,Kustermann Monika¹³,Thomson Rachel E.¹⁴^ORCID,Larsson Lars¹⁴¹⁵¹⁶^ORCID,Loveland Kate L.¹⁷¹⁸^ORCID,Costelli Paola¹⁹^ORCID,Megighian Aram³^ORCID,Merigliano Stefano⁶,Penna Fabio¹⁹^ORCID,Gregorevic Paul¹⁴²⁰²¹^ORCID,Sandri Marco²³⁷²²^ORCID

Affiliation:

1. Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.

2. Veneto Institute of Molecular Medicine, 35129 Padova, Italy.

3. Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.

4. Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.

5. Biomedicine Discovery Institute, Department of Physiology, Monash University, Melbourne, VIC 3800, Australia.

6. Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.

7. Myology Center, University of Padova, 35122 Padua, Italy.

8. Department of Structural and Functional Biology, Biology Institute, University of Campinas, Campinas, São Paulo 13083-97, Brazil.

9. The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.

10. Theme Cancer, Karolinska University Hospital, Solna 171 76, Sweden.

11. Department of Radiology, Padova General Hospital, 35121 Padova, Italy.

12. Department of Medicine, University Hospital of Padova, 35121 Padova, Italy.

13. Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria.

14. Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

15. Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

16. Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA.

17. Centre for Reproductive Health. Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.

18. Department of Molecular and Translational Sciences, and Anatomy and Developmental Biology, Monash University, VIC 3800, Australia.

19. Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.

20. Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia.

21. Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA.

22. Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.

Abstract

Neuromuscular junction remodeling and deterioration due to impaired BMP signaling are associated with cancer-induced muscle wasting.

Funder

National Multiple Sclerosis Society Michigan Chapter, Inc.

Advanced Foods and Materials Canada

Institute of Genetics

European Research Council

National Health and Medical Research Council

Swedish Foundation for International Cooperation in Research and Higher Education

State Government of Victoria

Politechnika Gdanska

Advanced Science Institute

Alimentary Health

Fondazione AIRC per la Ricerca sul Cancro

H2020-MSCA-RISE

Studies

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference92 articles.

1. Definition and classification of cancer cachexia: an international consensus

2. Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”

3. Cachexia as a major underestimated and unmet medical need: facts and numbers

4. Cancer Cachexia and Fat–Muscle Physiology

5. Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

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