A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation

Author:

Jobin Katarzyna12ORCID,Stumpf Natascha E.1ORCID,Schwab Sebastian13ORCID,Eichler Melanie1,Neubert Patrick4,Rauh Manfred5,Adamowski Marek1,Babyak Olena1,Hinze Daniel6,Sivalingam Sugirthan6ORCID,Weisheit Christina17ORCID,Hochheiser Katharina1ORCID,Schmidt Susanne V.8ORCID,Meissner Mirjam1ORCID,Garbi Natalio1,Abdullah Zeinab1,Wenzel Ulrich9,Hölzel Michael6,Jantsch Jonathan4,Kurts Christian110ORCID

Affiliation:

1. Institute of Experimental Immunology, University Hospital of Bonn, Rheinische Friedrich Wilhelm University, 53127 Bonn, Germany.

2. Institute for Systems Immunology, Julius Maximilian University of Würzburg, Würzburg, Germany.

3. Medizinische Klinik I, University Hospital of Bonn, Rheinische Friedrich Wilhelm University, 53127 Bonn, Germany.

4. Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

5. Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraβe 15, 91054 Erlangen, Germany.

6. Institute of Experimental Oncology, University Hospital of Bonn, Rheinische Friedrich Wilhelm University, Bonn, Germany.

7. Department of Anesthesiology and Intensive Care Medicine, University Hospital of Bonn, Rheinische Friedrich Wilhelm University, 53127 Bonn, Germany.

8. Institute of Innate Immunity, University Hospital of Bonn, Rheinische Friedrich Wilhelm University, 53127 Bonn, Germany.

9. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

10. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia.

Abstract

A high-salt diet in mice and humans impairs neutrophil antibacterial functions by dysregulating immunosuppressive steroid hormones.

Funder

Horizon 2020 Framework Programme

Deutsche Forschungsgemeinschaft

Bundesministerium fur Wirtschaft und Technologie

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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