Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI-Reference-Cited by-同舟云学术

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI

Published:2020-05-13 Issue:543 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yu Xiaowen¹²³^ORCID,Xu Man¹²³^ORCID,Meng Xia¹²³^ORCID,Li Shumin¹²³^ORCID,Liu Qianqi⁴^ORCID,Bai Mi¹²³^ORCID,You Ran¹²³^ORCID,Huang Songming¹²³^ORCID,Yang Li⁵,Zhang Yue¹²³^ORCID,Jia Zhanjun¹²³^ORCID,Zhang Aihua¹²³⁶^ORCID

Affiliation:

1. Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China.

2. Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China.

3. Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing 210029, China.

4. Department of Endocrinology, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China.

5. Department of Nephrology, Peking University First Hospital, Beijing 100034, China.

6. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China.

Abstract

PXR is crucial for protecting against AKI by targeting the AKR1B7/mitochondrial metabolism axis.

Funder

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference54 articles.

1. Acute kidney injury—epidemiology, outcomes and economics

2. Prevention of rhabdomyolysis‐induced acute kidney injury – A DASAIM/DSIT clinical practice guideline

3. Long-term prognosis after acute kidney injury (AKI): what is the role of baseline kidney function and recovery? A systematic review

4. Estimated Glomerular Filtration Rate Is a Poor Predictor of Concentration for a Broad Range of Uremic Toxins

5. Mitochondrial biogenesis and clearance: a balancing act

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