GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats-Reference-Cited by-同舟云学术

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

Published:2020-03-04 Issue:533 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Fortin Samantha M.¹^ORCID,Lipsky Rachele K.¹²^ORCID,Lhamo Rinzin¹^ORCID,Chen Jack¹^ORCID,Kim Eun¹^ORCID,Borner Tito²,Schmidt Heath D.¹²,Hayes Matthew R.¹²^ORCID

Affiliation:

1. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

The anorectic effects of liraglutide are mediated by glucagon-like peptide-1 receptors expressed on GABAergic neurons in the nucleus tractus solitarius.

Funder

NIH Office of the Director

Novo Nordisk

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference114 articles.

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5. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats;Tang-Christensen M.;Am. J. Physiol.,1996

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