Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes-Reference-Cited by-同舟云学术

Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

Published:2020-08-12 Issue:556 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Calvier Laurent¹²^ORCID,Demuth Guillaume¹²,Manouchehri Navid³,Wong Connie¹²^ORCID,Sacharidou Anastasia⁴^ORCID,Mineo Chieko⁴^ORCID,Shaul Philip W.⁴,Monson Nancy L.³,Kounnas Maria Z.⁵,Stüve Olaf³⁶,Herz Joachim¹²³⁷^ORCID

Affiliation:

1. Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2. Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

3. Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

4. Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

5. Reelin Therapeutics Inc. La Jolla, CA 92037, USA.

6. Department of Neurology, VA North Texas Health Care System, Medical Service, Dallas, TX 75390, USA.

7. Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Anti-Reelin is a therapeutic approach that selectively targets endothelial adhesion of leukocytes, blocking neuroinflammation and demyelination.

Funder

BrightFocus Foundation

NHLBI

DFG

Bluefield Project to Cure FTD

Harrington Scholar Innovator Award

NINDS and NIA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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