Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env-Reference-Cited by-同舟云学术

Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env

Published:2021-11-24 Issue:621 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Escolano Amelia¹^ORCID,Gristick Harry B.²^ORCID,Gautam Rajeev³^ORCID,DeLaitsch Andrew T.²^ORCID,Abernathy Morgan E.²^ORCID,Yang Zhi²^ORCID,Wang Haoqing²^ORCID,Hoffmann Magnus A.G.²^ORCID,Nishimura Yoshiaki³^ORCID,Wang Zijun¹^ORCID,Koranda Nicholas²,Kakutani Leesa M.²^ORCID,Gao Han²,Gnanapragasam Priyanthi N. P.²,Raina Henna³^ORCID,Gazumyan Ana¹^ORCID,Cipolla Melissa¹^ORCID,Oliveira Thiago Y.¹^ORCID,Ramos Victor¹^ORCID,Irvine Darrell J.⁴^ORCID,Silva Murillo⁴^ORCID,West Anthony P.²^ORCID,Keeffe Jennifer R.²^ORCID,Barnes Christopher O.²^ORCID,Seaman Michael S.⁵^ORCID,Nussenzweig Michel C.¹⁶^ORCID,Martin Malcolm A.³^ORCID,Bjorkman Pamela J.²^ORCID

Affiliation:

1. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

2. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

3. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

6. Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

Abstract

Sequential immunization elicits antibodies against the V3-glycan patch of HIV-1 Env in rhesus macaques and also induces off-target antibody responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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