β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development

Author:

Rao Shuyun12ORCID,Yang Xiaochun13ORCID,Ohshiro Kazufumi1ORCID,Zaidi Sobia13,Wang Zhanhuai24ORCID,Shetty Kirti5,Xiang Xiyan13ORCID,Hassan Md. Imtaiyaz6ORCID,Mohammad Taj6ORCID,Latham Patricia S.27ORCID,Nguyen Bao-Ngoc2,Wong Linda89ORCID,Yu Herbert10ORCID,Al-Abed Yousef1,Mishra Bibhuti111ORCID,Vacca Michele12ORCID,Guenigault Gareth13ORCID,Allison Michael E. D.14ORCID,Vidal-Puig Antonio121516ORCID,Benhammou Jihane N.17ORCID,Alvarez Marcus18,Pajukanta Päivi1819,Pisegna Joseph R.20ORCID,Mishra Lopa123

Affiliation:

1. Institute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.

2. Center for Translational Medicine, Department of Surgery, George Washington University, Washington DC 20037, USA.

3. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.

4. Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

5. Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

6. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.

7. Department of Pathology, George Washington University, Washington DC 20037, USA.

8. Cancer Biology Department, University of Hawaii Cancer Center, HI 96813, USA.

9. Department of Surgery, John A. Burns School of Medicine, University of Hawaii, HI 96813, USA.

10. Epidemiology Program, University of Hawaii Cancer Center, HI 96813, USA.

11. Department of Neurology, Northwell Health, Manhasset, NY 11030, USA.

12. TVPLab, Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.

13. CN Bio Innovations Limited, Cambridge CB4 0WH, UK.

14. Liver Unit, Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge CB2 0QQ, UK.

15. Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

16. Cambridge University Nanjing Centre of Technology and Innovation, Jiangbei Area, Nanjing 210000, China.

17. Vatche and Tamar Manoukian Division of Digestive Diseases and Gastroenterology, Hepatology and Parenteral Nutrition, David Geffen School of Medicine at UCLA and VA Greater Los Angeles HCS, Los Angeles, CA 90095, USA.

18. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

19. Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

20. Department of Medicine and Human Genetics, Division of Gastroenterology, Hepatology and Parenteral Nutrition, David Geffen School of Medicine at UCLA and VA Greater Los Angeles HCS, Los Angeles, CA 90095, USA.

Abstract

Targeting SBPTN1 with siRNA has the potential to treat NASH and prevent HCC.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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