Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Author:

Dendrou Calliope A.1,Cortes Adrian12,Shipman Lydia1,Evans Hayley G.1,Attfield Kathrine E.3,Jostins Luke2,Barber Thomas1,Kaur Gurman3,Kuttikkatte Subita Balaram3,Leach Oliver A.1,Desel Christiane1,Faergeman Soren L.14,Cheeseman Jane5,Neville Matt J.56,Sawcer Stephen7,Compston Alastair7,Johnson Adam R.8,Everett Christine8,Bell John I.9,Karpe Fredrik56,Ultsch Mark8,Eigenbrot Charles8,McVean Gil2,Fugger Lars134

Affiliation:

1. Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

2. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

3. Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

4. Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark.

5. Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LE, UK.

6. National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals Trust, Churchill Hospital, Oxford OX3 7LE, UK.

7. Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

8. Structural Biology and Biochemical Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

9. University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7DG, UK.

Abstract

Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically for treating autoimmune diseases.

Funder

Alan and Babette Sainsbury Charitable Fund

Naomi Bramson Trust

Clinical Neuroimmunology Fund

Oxford BRC

Oak Foundation

Rosetrees Trust

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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